T follicular helper cells, T follicular regulatory cells and autoimmunity
نویسندگان
چکیده
منابع مشابه
T follicular helper cells, T follicular regulatory cells and autoimmunity.
CD4(+)T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity. Tfh cell differentiation depends on various factors including cell-surface molecule interactions, extracellular cytokines and multip...
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Production of high-affinity pathogenic autoantibodies appears to be central to the pathogenesis of lupus. Because normal high-affinity antibodies arise from germinal centers (GCs), aberrant selection of GC B cells, caused by either failure of negative selection or enhanced positive selection by follicular helper T (T(FH)) cells, is a plausible explanation for these autoantibodies. Mice homozygo...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2015
ISSN: 0953-8178,1460-2377
DOI: 10.1093/intimm/dxv079